EOCalc.com also shows a very low safe usage rate for anise EO. It is a known skin sensitizer and can react with some medications (primarily if used orally). Here is some info about Anise from Hopewell Essential Oils (a site that I like because it frequently quotes Tisserand and other respected authors):
Children? Avoid use with children under 5 (due to estrogenic properties).
Pregnancy/Breastfeeding? Not suitable due to (E) anethole content (Tisserand/Young). Balacs writes in Hormones and Health: "The oestrogenic effects of aniseed are relatively weak but suggest that it would be safe not to use orally during pregnancy and breast feeding."
Medication/Health Condition?
Contraindicated All Routes: Endometriosis, Estrogen-dependent Cancers
Caution Orally: Diabetes, Diuretic and Anticoagulant medication (such as aspirin, heparin, warfarin), Renal insufficiency, Edematous disorders, Major Surgery and Childbirth (up to one week before and after), Peptic Ulcers, Hemophilia and other Bleeding disorders, Severe Hepatic (liver) or Renal (kidney) impairment, Hypertensive or Diabetic Retinopathy, Thrombocytopenia (decreased platelet count), Vasculitis
[Contraindicated orally because Anise "may inhibit platelet aggregation based on in vitro data either for the oil or a major constituent." Essential Oil Safety by Tisserand/Young, page 117.]